Systematic Review of the Economic Burden of Dengue Infection to the Healthcare in South East Asia (SEA)

Authors

  • Mohd ‘Ammar Ihsan Ahmad Zamzuri State Health Department of Negeri Sembilan, Ministry of Health Malaysia, Jalan Rasah, 70300 Seremban, Negeri Sembilan, Malaysia
  • Shahrul Azhar Md Hanif Dr.
  • Ahmad Farid Nazmi Abdul Halim Department of Public Health Medicine, Faculty of Medicine, National University of Malaysia Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia
  • Muhammad Ridzwan Rafi’i Department of Public Health Medicine, Faculty of Medicine, National University of Malaysia Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia
  • Siti Najiha Md Asari Department of Public Health Medicine, Faculty of Medicine, National University of Malaysia Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia
  • Rozita Hod Department of Public Health Medicine, Faculty of Medicine, National University of Malaysia Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia
  • Rahmat Dapari Department of Community Health, Universiti Putra Malaysia, 43400 Serdang, Malaysia
  • Hasanain Faisal Ghazi College of Nursing, Al-Bayan University, Baghdad, Iraq
  • Mohd Rohaizat Hassan Department of Public Health Medicine, Faculty of Medicine, National University of Malaysia Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia

Keywords:

dengue, economic burden, costing, cost of illness, cost of program, financing

Abstract

Introduction:

Dengue remains a public health threat that consumes a significant number of resources for its prevention and control. This systematic review aimed to solidify recent costing evidence in dengue management among South East Asian (SEA) countries.

Methods:

All studies conducted between 2010 and 2020 were retrieved using four international databases i.e. PubMed, Scopus, Web of Science, and Emerald Insight. The review was reported according to PRISMA guidelines. Quality assessments were done independently by two reviewers using a checklist adapted for the cost of illness studies.

Results:

We identified 13 original articles representing several SEA countries. Among the common reported costing measure include total cost/ health expenditure; direct medical cost; direct non-medical cost; and indirect cost. The estimated total cost for dengue management varied between countries largely due to the difference in the total incidence of dengue cases. The estimated cost spent on dengue per capita GDP ranges from less than 0.001% to 0.1%, depending on the recorded number of dengue cases of the year. The majority of the articles focused on the economic burden from the perspective of treatment such as hospitalization and ambulatory care.

Conclusions:

In a nutshell, the economic burden of managing dengue infection is costly and the evidence suggests a steady increase in health expenditure with the growing number of dengue cases.

References

Soares-Pinheiro VC, Dasso-Pinheiro W, Trindade-Bezerra JM, Tadei WP. Eggs viability of Aedes aegypti Linnaeus (Diptera, Culicidae) under different environmental and storage conditions in Manaus, Amazonas, Brazil. Brazilian J Biol. 2016;77(2):396–401.

Trpis M. Dry season survival of Aedes aegypti eggs in various breeding sites in the Dar es Salaam area, Tanzania. Bull World Health Organ [Internet]. 1972 [cited 2020 Aug 20];47(3):433–7. Available from: /pmc/articles/PMC2480724/?report=abstract

WHO WHO. Dengue and severe dengue [Internet]. [cited 2021 Jan 21]. Available from: https://www.who.int/news-room/fact-sheets/detail/dengue-and-severe-dengue

Lum LCS, Ng CJ, Khoo EM. Managing dengue fever in primary care: A practical approach [Internet]. Vol. 9, Malaysian Family Physician. Academy of Family Physicians of Malaysia; 2014 [cited 2021 Jan 22]. p. 2–10. Available from: /pmc/articles/PMC4399402/?report=abstract

Wilder-Smith A, Flasche S, Smith PG. Vaccine-attributable severe dengue in the Philippines. Lancet. 2019;394(10215):2151-2.

VECTOR MANAGEMENT AND DELIVERY OF VECTOR CONTROL SERVICES. 2009 [cited 2021 Jan 22]; Available from: https://www.ncbi.nlm.nih.gov/books/NBK143163/

Kumar S, Williams AC, Sandy JR. How do we evaluate the economics of health care? Eur J Orthod [Internet]. 2006 Dec [cited 2021 Jan 22];28(6):513–9. Available from: https://pubmed.ncbi.nlm.nih.gov/17035484/

Liyanage P, Rocklov J, Tissera H, Palihawadana P, Wilder-Smith A, Tozan Y. Evaluation of intensified dengue control measures with interrupted time series analysis in the Panadura Medical Officer of Health division in Sri Lanka: a case study and cost-effectiveness analysis. LANCET Planet Heal. 2019 May;3(5):E211–8.

Ganasegeran K, Hor CP, Jamil MFA, Loh HC, Noor JM, Hamid NA, et al. A systematic review of the economic burden of type 2 diabetes in Malaysia. Int J Environ Res Public Health. 2020;17(16):1–23.

Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol [Internet]. 2009 Oct 1 [cited 2021 Feb 1];62(10):1006–12. Available from: https://pubmed.ncbi.nlm.nih.gov/19631508/

Drummond MF, O’Brien B, Stoddart GL, Torrance GW. Methods for the Economic Evaluation of Health Care Programmes, Second Edition [Internet]. Vol. 14, American Journal of Preventive Medicine. 1998 [cited 2021 Jan 21]. p. 243. Available from: https://global.oup.com/academic/product/methods-for-the-economic-evaluation-of-health-care-programmes-9780199665884?cc=my&lang=en&

Mutyambizi C, Pavlova M, Chola L, Hongoro C, Groot W. Cost of diabetes mellitus in Africa: A systematic review of existing literature. Global Health. 2018;14(1):1–13.

Shepard DS, Undurraga EA, Lees RS, Halasa Y, Lum LCS, Ng CW. Use of multiple data sources to estimate the economic cost of dengue illness in Malaysia. Am J Trop Med Hyg [Internet]. 2012;87(5):796–805. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84869116996&doi=10.4269%2Fajtmh.2012.12-0019&partnerID=40&md5=21f104a3fdd13462d9fd482b409a379e

Shepard DS, Undurraga EA, Halasa YA. Economic and disease burden of dengue in Southeast Asia. Gubler DJ, editor. PLoS Negl Trop Dis [Internet]. 2013 Feb 21 [cited 2020 Aug 18];7(2):e2055. Available from: https://dx.plos.org/10.1371/journal.pntd.0002055

Sridhar S, Luedtke A, Langevin E, Zhu M, Bonaparte M, Machabert T, et al. Effect of Dengue Serostatus on Dengue Vaccine Safety and Efficacy. N Engl J Med [Internet]. 2018 Jun 13 [cited 2021 Feb 3]; Available from: https://www.nejm.org/doi/full/10.1056/NEJMoa1800820

WHO WHO. Weekly epidemiological record Relevé épidémiologique hebdomadaire Sommaire. 2016 [cited 2021 Feb 3]; Available from: http://www.who.int/wer

Tarragona S, Monteverde M, Marchioni S, Caporale J, Pereiro AC, Palacios JM. [Dengue in Argentina: an economic analysis of the impact of the 2009 epidemic]. Salud Colect. 2012;8(2):151–62.

Hodgson TA, Meiners MR. Cost-of-illness methodology: a guide to current practices and procedures. Milbank Mem Fund Q Health Soc. 1982;60(3):429–62.

de Oliveira ML, Santos LMP, da Silva EN. Methodological foundations for cost-of-illness studies in Brazil. Rev Nutr [Internet]. 2014 [cited 2021 Feb 3];27(5):585–95. Available from: http://dx.doi.org/10.1590/1415-52732014000500007

Bravo L, Roque VG, Brett J, Dizon R, L’Azou M. Epidemiology of Dengue Disease in the Philippines (2000–2011): A Systematic Literature Review. Horstick O, editor. PLoS Negl Trop Dis [Internet]. 2014 Nov 6 [cited 2021 Feb 3];8(11):e3027. Available from: https://dx.plos.org/10.1371/journal.pntd.0003027

Ernstsson O, Gyllensten H, Alexanderson K, Tinghög P, Friberg E, Norlund A. Cost of Illness of Multiple Sclerosis - A Systematic Review. Fujinami RS, editor. PLoS One [Internet]. 2016 Jul 13 [cited 2021 Feb 3];11(7):e0159129. Available from: https://dx.plos.org/10.1371/journal.pone.0159129

Tan SS, Rutten FF, van Ineveld BM, Redekop WK, Hakkaart-van Roijen L. Comparing methodologies for the cost estimation of hospital services. Eur J Health Econ. 2009;10(1):39-45.

da Silva NS, Undurraga EA, Verro AT, Nogueira ML. Comparison between the traditional (1997) and revised (2009) WHO classifications of dengue disease: a retrospective study of 30 670 patients. Trop Med Int Heal [Internet]. 2018 Dec 1 [cited 2021 Feb 4];23(12):1282–93. Available from: http://doi.wiley.com/10.1111/tmi.13155

Andersson F. Methodological Aspects of International Drug Price Comparisons [Internet]. Vol. 4, PharmacoEconomics. Pharmacoeconomics; 1993 [cited 2021 Jan 21]. p. 247–56. Available from: https://pubmed.ncbi.nlm.nih.gov/10146914/

Pham LD, Phung NHT, Le NTD, Vo TQ. Economic report on the cost of dengue fever in Vietnam: case of a provincial hospital. Clin OUTCOMES Res. 2017;9:1–8.

Packierisamy PR, Ng CW, Dahlui M, Inbaraj J, Balan VK, Halasa YA, et al. Cost of dengue vector control activities in Malaysia. Am J Trop Med Hyg. 2015;93(5):1020–7.

Carrasco LR, Lee LK, Lee VJ, Ooi EE, Shepard DS, Thein TL, et al. Economic impact of dengue illness and the cost-effectiveness of future vaccination programs in Singapore. PLoS Negl Trop Dis. 2011;5(12).

Downloads

Published

05-02-2025

How to Cite

Ahmad Zamzuri, M. ‘Ammar I., Md Hanif, S. A., Abdul Halim, A. F. N., Rafi’i, M. R., Md Asari, S. N., Hod, R., Dapari, R., Habasha, H. F. G., & Hassan, M. R. (2025). Systematic Review of the Economic Burden of Dengue Infection to the Healthcare in South East Asia (SEA). International Journal of Public Health Research, 15(1), 2087–2104. Retrieved from https://spaj.ukm.my/ijphr/index.php/ijphr/article/view/494

Most read articles by the same author(s)

1 2 3 > >>