Kesan Pendedahan Mikroplastik terhadap Jantung: Ulasan Naratif
Effects of Microplastic Exposure on the Heart: A Narrative Review
Keywords:
Plastik, Mikroplastik, Jantung, Ulasan naratifAbstract
Introduction
World Health Organization (WHO) reported that heart disease is among the global main cause of death. The significant environmental factor for heart disease is microplastic exposure. In cardiology, microplastic has been widely used due to stability and biocompatibility. Therefore, this narrative aimed to study the effect of microplastic exposure towards heart. The findings will contribute to evidence-based medicine in heart disease prevention strategies.
Methodology
A literature search was conducted on ninth November 2024, across three scientific databases of Scopus, PubMed, and Web of Science using specified keywords like microplastic and heart. The target was original articles published between 2019 and 2024.
Result
A total of six articles published within 2023 and 2024 have been analysed. All articles reported that microplastic exposure triggers the oxidative process and inflammatory response of cardiomyocyte cells. These processes led to myocardial ischemia and infarction that resulted in heart failure.
Conclusion
Microplastic exposure is a new risk factor for heart disease. The findings should be integrated in public health promotion programme and the clinical practice guideline of cardiovascular disease for multilevel prevention.
References
Rujukan
Di Cesare M, Perel P, Taylor S, Kabudula C, Bixby H, Gaziano TA, et al. The heart of the world. Global heart. 2024;19(1).
WHO. Cardiovascular diseases (CVDs) 2024 [Available from: https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)?gad_source=1&gclid=Cj0KCQjw99e4BhDiARIsAISE7P_rrwHpdYSOu537MXboJrJ6S7ZcJ5a0Tw4JdgXUMvHij6llNV_DDPQaAlD3EALw_wcB.
Schmid C, Cozzarini L, Zambello E. Microplastic's story. Marine pollution bulletin. 2021;162:111820.
Rushdi IW, Rusidi RS, Khairul WM, Hamzah S, Khalik W, Anuar ST, et al. Microplastics in the environment: Properties, impacts and removal strategies. Malaysian Journal of Analytical Sciences. 2023;27(6):1216-35.
de Oliveira RB, Pelepenko LE, Masaro DA, Lustosa GM, de Oliveira MC, Roza NA, et al. Effects of microplastics on the kidneys: a narrative review. Kidney International. 2024;106(3):400-7.
Auta HS, Emenike CU, Fauziah SH. Distribution and importance of microplastics in the marine environment: a review of the sources, fate, effects, and potential solutions. Environment international. 2017;102:165-76.
Dewika M, Kantha N, Markandan K, Nagaratnam S, Irfan NA, Khalid M. Microplastics release from coronary catheters: Insights from catheter analysis. Chemosphere. 2024;366:143428.
Prattichizzo F, Ceriello A, Pellegrini V, La Grotta R, Graciotti L, Olivieri F, et al. Micro-nanoplastics and cardiovascular diseases: evidence and perspectives. European Heart Journal. 2024;45(38):4099-110.
Yang Y, Xie E, Du Z, Peng Z, Han Z, Li L, et al. Detection of various microplastics in patients undergoing cardiac surgery. Environmental Science & Technology. 2023;57(30):10911-8.
Persiani E, Cecchettini A, Ceccherini E, Gisone I, Morales MA, Vozzi F. Microplastics: a matter of the heart (and vascular system). Biomedicines. 2023;11(2):264.
Kuang Q, Gao L, Feng L, Xiong X, Yang J, Zhang W, et al. Toxicological effects of microplastics in renal ischemia–reperfusion injury. Environmental Toxicology. 2024;39(4):2350-62.
Walczak AP, Hendriksen PJ, Woutersen RA, van der Zande M, Undas AK, Helsdingen R, et al. Bioavailability and biodistribution of differently charged polystyrene nanoparticles upon oral exposure in rats. Journal of Nanoparticle Research. 2015;17:1-13.
Zhang M, Shi J, Zhu Y, Pan H, Song L, Deng H. Polystyrene nanoplastics induce vascular stenosis via regulation of the PIWI-interacting RNA expression profile. Environmental Pollution. 2024;345:123441.
Deng L, Li M, Jiang Z, Xiang G, He S, Zhang H, et al. Cobalt nanoparticles attenuate microplastic-induced vascular endothelial injury via Nrf2 pathway activation. Science of the Total Environment. 2024;951.
Wang T, Yi Z, Liu X, Cai Y, Huang X, Fang J, et al. Multimodal detection and analysis of microplastics in human thrombi from multiple anatomically distinct sites. Ebiomedicine. 2024;103.
Zhang T, Yang S, Ge Y, Yin L, Pu Y, Gu Z, et al. Unveiling the Heart’s Hidden Enemy: Dynamic Insights into Polystyrene Nanoplastic-Induced Cardiotoxicity Based on Cardiac Organoid-on-a-Chip. ACS Nano. 2024.
Yang Y, Zhang F, Jiang Z, Du Z, Liu S, Zhang M, et al. Microplastics are associated with elevated atherosclerotic risk and increased vascular complexity in acute coronary syndrome patients. Particle and Fibre Toxicology. 2024;21(1):34.
Zhou Y, Wu Q, Li Y, Feng Y, Wang Y, Cheng W. Low-dose of polystyrene microplastics induce cardiotoxicity in mice and human-originated cardiac organoids. Environment International. 2023;179:108171.
Li J, Weng H, Liu S, Li F, Xu K, Wen S, et al. Embryonic exposure of polystyrene nanoplastics affects cardiac development. Science of The Total Environment. 2024;906:167406.
Yang YX, Zhang F, Jiang ZL, Du ZY, Liu S, Zhang M, et al. Microplastics are associated with elevated atherosclerotic risk and increased vascular complexity in acute coronary syndrome patients. Particle and Fibre Toxicology. 2024;21(1).
Wang K, Du Y, Li P, Guan C, Zhou M, Wu L, et al. Nanoplastics causes heart aging/myocardial cell senescence through the Ca2+/mtDNA/cGAS-STING signaling cascade. Journal of Nanobiotechnology. 2024;22(1).
Yu C, Jin D, Hu X, He W, Li G. An Overview of Management Status and Recycling Strategies for Plastic Packaging Waste in China. Recycling. 2023;8(6):90.
Zhang M, Shi J, Zhou J, Song L, Ding J, Deng HP, et al. N6-methyladenosine methylation mediates non-coding RNAs modification in microplastic-induced cardiac injury. Ecotoxicol Environ Saf. 2023;262:115174.
Marfella R, Prattichizzo F, Sardu C, Fulgenzi G, Graciotti L, Spadoni T, et al. Microplastics and nanoplastics in atheromas and cardiovascular events. New England Journal of Medicine. 2024;390(10):900-10.
Glazier HA. Microplastics and Nanoplastics in Atheromas. The New England journal of medicine. 2024;390(18):1727-8.
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